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主要研究方向

主要研究方向：

1. 绿色有机合成方法学（可见光催化或电化学产生的可控自由基反应及其合成应用）

2.发展小分子催化的高选择性、高效性的自由基（光化学或电化学）参与的不对称合成方法学

3.手性药物及靶向抗癌药物的理性设计合成及相关应用

热烈欢迎硕博生，交流生及研究助理加入我们课题组！

主要工作业绩

主要工作业绩：

 郑柯博士先后致力于不对称催化剂的设计合成，手性药物合成，神经类药物及抗癌药物和抗癌新靶点等多个前沿性领域的研究，取得了一系列创新性的优秀成果；其丰富的跨学科研究经历，为今后的科研工作，特别是交叉学科和转化药学的研究打下了扎实的基础。回国入职四川大学开始独立工作之后，郑柯博士主要围绕以药物分子为导向的绿色有机合成方法学的研究。重点开展基于利用小分子的弱相互作用来稳定光催化和电催化反应中的高活性中间体，利用产生的高活性的自由基物种来实现以前传统历程不能实现的反应，实现新反应的拓展。同时引入具有手性结构的小分子催化剂来实现一系列自由基参与的不对称催化反应，实现一些以前较难实现的反应，为合成复杂分子和手性药物分子提供一个更绿色、高效的合成方法。最后，我们利用这些方法自身特点和流动化学相结合，为后续大规模的生产创造了便利的条件。  

 郑柯博士已经在Chem. Rev.，J.   Am. Chem. Soc.，Angew. Chem. Int. Ed.，Chem.   Commun.，Chem. -Eur. J.，ACS Med. Chem. Lett.以及J.   Med. Chem. 等本领域权威刊物发表SCI论文和专著近30篇，国际专利1篇、美国专利2篇，并多次被Synfacts杂志刊登并给予了高度的评价。

主要奖励及荣誉

2012 “ 四川省优秀毕业研究生”称号

2012 “ 四川大学优秀毕业研究生”称号

2010教育部自然科学奖一等奖（第九完成人）

2010教育部第一届“博士研究生学术新人奖”

2011唐敖庆化学奖

2007-2010曾先 后获得四川大学“振兴奖学金”（2007），“陶氏化学教育发展奖学金”（2008），“宝钢优秀学生奖”（2009），“中石化奖学金”（2010）

2007-2011连续4年获得四川大学创新人才一等奖

2007-2009   “ 四川大学双十佳优秀学生模范”

2007-2012连续5年获得“四川大学研究生一等奖学金”及“四川大学优秀研究生”称号

2007 “四川省优秀本科毕业生”称号及“四川大学2007届本科优秀毕业生”称号

代表性成果(获奖成果、专著、论文、专利)

1.Liquan Yang, Zhaoran Liu, Yujun Li, Ning Lei, Yanling Shen, and Ke   Zheng* “Electrochemically Enabled C3-Formylation and -Acylation of   Indoles with Aldehydes” Org. Lett. 2019, 21, 7702−7707.

2.Dong Jing,^# Cong Lu,^# Zhuo Chen, Songyang   Jin, Lijuan Xie, Ziyi Meng, Zhishan Su, Ke Zheng*“Light-Driven   Intramolecular C-N Cross-Coupling via a Long-Lived Photoactive Photoisomer   Complex”Angew. Chem. Int. Ed.2019,58,   14666 –14672.

3.Cong Lu^# Zhishan Su,^# Dong Jing, Songyang   Jin, Lijuan Xie, Liangrui, Li and Ke Zheng*

 “Intramolecular   Reductive Cyclization of o-Nitroarenes via Biradical Recombination”Org.   Lett. 2019, 21, 1438−1443.

4.Yujun Li, Qi Yang, Liquan Yang, Ning Lei and Ke Zheng*   “A scalable   electrochemical dehydrogenative cross-coupling of P(O)H compounds with   RSH/ROH”Chem. Commun., 2019, 55, 4981-4984.

5.Angelo Aguilar,^#Ke Zheng,^#et al. and   Shaomeng Wang * “Structure-Based   Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage   Leukemia (Menin-MLL) Protein-Protein Interaction”J.   Med. Chem. 2019, 62, 6015−6034.

6.Lijuan Xie, Cong Lu, Dong Jing, Xinrui Ou, and Ke Zheng*   “Metal-Free Synthesis   of Polycyclic Quinazolinones Enabled by a (NH4)2S2O8-Promoted Intramolecular   Oxidative Cyclization”Eur. J. Org. Chem. 2019,   3649−3653.

7.Ke Zheng, Xiaohua Liu, and Xiaoming Feng* “Recent Advances in   Metal-Catalyzed Asymmetric 1,4-Conjugate Addition (ACA) of Nonorganometallic Nucleophiles”Chem.   Rev. 2018, 118, 7586−7656.

8.Shilin Xu^#, Angelo Aguilar^#, Tianfeng Xu^#,   Ke Zheng^#, et al. and Shaomeng Wang * “Design of the   First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL   Protein–Protein Interaction”Angew.   Chem. Int. Ed. 2018, 57,1601−1605.

9.Ke Zheng, Chul Min Park, Sarah Iqbal, Pamela   Hernandez, HaJeung Park, Philip V. LoGrasso,* and Yangbo Feng*   “Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal   Kinase (JNK) Inhibitors” ACS Med. Chem. Lett.,2015,6,   413-418.

10.Yan Yin, Ke Zheng, Nibal Eid, et al, Philip V.   LoGrasso,* and Yangbo Feng*“Bis-aryl Urea Derivatives as Potent and Selective   LIM Kinase (Limk) Inhibitors” J. Med. Chem.2015,58(4),   1846-1861.

11.Ke Zheng, Sarah Iqbal, Pamela Hernandez, HaJeung   Park, Philip V. LoGrasso,* and Yangbo Feng* “Design and Synthesis of Highly   Potent and Selective JNK3 Inhibitors: SAR Studies on Aminopyrozal   Derivatives” J. Med. Chem.2014,57, 10013-10030

12.Ke Zheng, Xiaohua Liu, Song Qin, Mingsheng Xie,   Lili Lin, Changwei Hu, and Xiaoming Feng* “Completely OH-Selective FeCl3   Catalyzed Prins Cyclization: Highly Stereoselective Synthesis of   4-OH-Tetrahydropyrans” J. Am. Chem. Soc. 2012,134,   17564−17573.

13.Ke Zheng, Lili Lin and Xiaoming Feng* “Chiral N,N '-Dioxide-Ni(II)   Complex Catalyzed Asymmetric Carbonyl-Ene Reaction of Ethyl   Trifluoropyruvate” Acta Chim. Sinica 2012, 70, 1785-1790.

14.Ke Zheng, Chengkai Yin, Xiaohua Liu, and Xiaoming Feng* “Catalytic   Asymmetric Addition of Alkyl Enol Ethers to 1,2-Dicarbonyl Compounds: Highly   Enantioselective Synthesis of Substituted 3-Alkyl-3-Hydroxyoxindoles” Angew.   Chem. Int. Ed.2011,50, 2573.

15.Ke Zheng,Xiaohua Liu, Jiannan Zhao, Yang Yang, Lili Lin and Xiaoming   Feng* “Highly Enantioselective Aza-Ene-Type Reaction Catalyzed by Chiral N,N’-dioxide-nickel(II)   Complex” Chem. Commun. 2010,46, 3771–3773.

16.Ke Zheng, Yang Yang, Jiannan Zhao, Chengkai Yin, Lili Lin, Xiaohua Liu and   Xiaoming Feng*. “Magnesium(II)-Catalyzed Asymmetric Ketone-Ene Reaction:   Stereocontrolled Access to Enantioenriched Trifluoromethyl-Substituted   Compounds” Chem. Eur. J. 2010,16, 9969.

17.Ke Zheng, Jian Shi, Xiaohua Liu, and Xiaoming Feng*. “Asymmetric   Carbonyl-Ene Reaction Catalyzed by Chiral N,N’-Dioxide -Nickel(II)   Complex: Remarkably Broad Substrate Scope” J. Am. Chem. Soc. 2008,   130, 15770-15771.

18.Ke Zheng, Bo Qin, Xiaohua Liu and Xiaoming Feng* “Highly   Enantioselective Allylation of a-Ketoesters Catalyzed by N,N’-Dioxide-In(III)   Complexes” J. Org. Chem.2007,72, 8478-8483.

19.Ke Zheng, Bo Qin,   Xiaohua Liu and Xiaoming Feng* “Highly Enantioselective Allylation of a-Ketoesters   Catalyzed by N,N’-Dioxide-In(III) Complexes” J. Org. Chem.2007,   72, 8478-8483.

20.Y. Yan, K. Zheng,   et al, Y. Feng* and P. LoGrasso*. “Bis-aryl Urea Derivatives as Potent and   Selective LIM Kinase (Limk) Inhibitors” J. Med. Chem.2015,58(4),   1846-1861.

21.X. Liu, K. Zheng,   and X. M. Feng. “Advancements in the Catalytic Asymmetric Intermolecular   Ene-Type Reactions” SYNTHESIS,2014;46: 2241-2257

22.J. N. Zhao, K.   Zheng, et al and X. M. Feng. “Asymmetric Mukaiyama Aldol Reaction   Catalyzed by C2-Symmetric N,N’-Dioxide–Ni(II) Complex” Synlett,   2011, 903-906.

23.P. HaJeung; I. Sarah;   H. Pamela; M. Rudy; K. Zheng, et al, Y. Feng and P. LoGrasso.   “Structural basis and biological consequences for JNK2/3 isoform selective   aminopyrazoles”Scientific reports2015, 5, 8047

24.K. Shen, X. H. Liu, K.   Zheng, et al and X. M. Feng. “Catalytic Asymmetric Synthesis of   3-(a-Hydroxy-b-carbonyl) Oxindoles by a Sc(III)-Catalyzed Direct Aldol-Type   Reaction” Chem. Eur. J.2010, 16, 3736-3742.

25.J. Shi, M. Wang, L.   He, K. Zheng, et al and X. M. Feng. “Enantioselective Michael addition   of malononitrile to chalcones catalyzed by a simple quinine-Al(OiPr)3 complex:   a simple method for thesynthesis of a chiral 4H-pyran derivative” Chem.   Commun. 2009, 45, 4711–4713.

26.B. Qin, X. H. Liu, J.   Shi, K. Zheng, et al and X. M. Feng. “Enantioselective Cyanosilylation   of a,a-Dialkoxy Ketones Catalyzed by Proline-Derived in-Situ-Prepared N-Oxide   as Bifunctional Organocatalys” J. Org. Chem.2007,72,   2374.