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主要研究方向

     在“光点击”化学反应中，利用两个高度环张力环融合在一起的策略，设计并合成了两代环丙烯亲偶极体，并且将其用到“光点击”生物正交化学反应中，提高10倍以上的反应动力学活性。利用其高活性且稳定的性质，首次合成ε-Sph赖氨酸衍生物，并将其用于基因编载重组蛋白质表达。实现超快速反应动力学并实现蛋白质残基的特定标记。这一系列的研究，在推进“光点击”生物正交反应在活体动物中的靶标分子的跟踪和操控研究项目中起到了中流砥柱承前启后的作用。

    欢迎有志于在生物正交化化学研究国际前沿做研究工作的学生到我实验室来从事科研工作！我们欢迎您投入到化学与分子生物学交叉学科的研究中，扩展视野。

研究方向选择： 

化学生物学（生物正交化学反应方向）

绿色有机合成化学

有机合成化学

主要工作业绩

余志鹏博士毕业于四川大学，师从冯小明教授。后赴美国SUNY UB化学系开展博士后研究工作，后升任SUNY UB 研究助理教授。致力于研究以“光点击化学”为基础的生物正交化学反应以及其在活体标记中的应用。在入职四川大学以来，致力于开拓化学学院化学生物学新方向的教学和科研工作。

主要开展应用于分子生物学探针活体生物分子的生物正交反应研究（有机化学反应为基础 的）。研究新型、高反应活性、高选择性的生物偶联反应。该类反应可在高度拥挤的活体细胞浆质内实现选择性的实现生物偶联，对生物分子添加新的功能性残基。该研究不仅仅是作为生物分子的小分子探针，而可以通过化学功能团的载入实现对特定生物代谢，基因的调控，细胞的信号传导等等生物过程的干预和操控。

获得的荣誉： 

2008          宝钢教育奖,宝钢优秀学生特等奖

2008-2009     四川大学创新人才一等奖

2007-2008     四川大学创新人才一等奖

2007-2008     四川大学优秀博士二等奖学金

2004-2005     四川大学优秀硕士研究生二等奖学金

2002          四川大学第四届学生科技节动画设计二等奖

代表性成果(获奖成果、专著、论文、专利)

 1. 合作作者发表的研究论文: Linmeng Zhang ,   Xiaocui Zhang ,   Zhuojun Yao ,   Shichao Jiang ,   Jiajie Deng ,   Bo Li ,and  Zhipeng Yu *, titled "Discovery of Fluorogenic Diarylsydnone-Alkene Photoligation: Conversion of ortho-Dual-Twisted Diarylsydnones into Planar Pyrazolines" J. Am. Chem. Soc., 2018, 140 (24), pp 7390–7394. 

2.合作作者发表的研究论文: Carlo P. Ramil, Maoqing Dong, Peng An, Tracey M. Lewandowski, Zhipeng Yu, Laurence J. Miller,* and Qing Lin ,* titled " Spirohexene-Tetrazine Ligation Enables Bioorthogonal Labeling of Class B G Protein-Coupled Receptors in Live Cells  " J. Am. Chem. Soc.,  2017 , 139,  13376–13386. 

  3.合作作者发表的研究论文: Yulin Tian, Marco Paolo Jacinto, Yu Zeng, Zhipeng Yu, Jun Qu, Wenshe R. Liu,* and Qing Lin*,titled "Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking " J. Am. Chem. Soc., 2017, 139, 6078–6081. 

   4.合作作者发表的研究论文: Carlo P. Ramil, Peng An,  Zhipeng Yu , and Qing Lin*,  tiltled "Sequence-specific 2-cyanobenzothiazole ligation " J. Am. Chem. Soc., J. Am. Chem. Soc.,  2016 , 138,  5499–5502 . 

   5.以第一作者发表的研究论文: Zhipeng Yu and Qing Lin*, titled "Design of Spiro[2.3]hex-1-ene, a Genetically Encodable Double-Strained Alkene for Superfast Photoclick Chemistry" J. Am. Chem. Soc., 2014, 136, 4153–4156. 

   6.以第一作者发表的研究论文: Zhipeng Yu, Tymish Y. Ohulchanskyy, Peng An, Paras N. Prasad, and Qing Lin*, titled "Fluorogenic, Two-Photon-Triggered Photoclick Chemistry in Live Mammalian Cells" J. Am. Chem. Soc.,2013,135, 16766–16769. 

   7.以第一作者发表的研究论文: Zhipeng Yu, Yanchao Pan, Zhiyong Wang, Jiangyun Wang,* Qing Lin*, titled "Genetically Encoded Cyclopropene Directs Rapid, Photoclick-Chemistry-Mediated Protein Labeling in Mammalian Cells" Angew. Chem. Int. Ed.2012,51, 10600-10604. 

   8.以第一作者发表的研究论文: Zhipeng Yu, Lok Yin Ho, and Qing Lin*, titled "Rapid, Photoactivatable Turn-On Fluorescent Probes Based on an Intramolecular Photo click Reaction" J. Am. Chem. Soc.,2011,133, 11912–11915. 

   9.以第一作者发表的研究论文: Zhipeng Yu, Lok Yin Ho, Zhiyong Wang, Qing Lin*, titled "Discovery of new photoactivatable diaryltetrazoles for photoclick chemistry via ‘scaffold hopping’" Bioorg. Med. Chem. Lett.,2011,21, 5033-5036.

   10.以第一作者发表的研究论文: Zhipeng Yu, Reyna K. V. Lim, Qing Lin*, titled "Synthesis of Macrocyclic Tetrazoles for Rapid Photoinduced Bioorthogonal 1,3-Dipolar Cycloaddition Reactions" Chem. Eur. J. 2010,16, 13325-13329 

   11.以合作作者发表的研究论文:Peng An, Zhipeng Yu and Qing Lin*, titled "Design of oligothiophene-based tetrazoles for laser-triggered photoclick chemistry in living cells" Chem. Commun., 2013,49,9920-9922. 

   12.以合作作者发表的研究论文:Peng An, Zhipeng Yu and Qing Lin*, titled "Design and Synthesis of Laser-Activatable Tetrazoles for a Fast and Fluorogenic Red-Emitting 1,3-Dipolar Cycloaddition Reaction" Org. Lett., 2013, 15, 5496–5499. 

   13.以合作作者发表的研究论文:Jiangyun Wang, Wei Zhang, Wenjiao Song, Yizhong Wang, Zhipeng Yu, Jiasong Li, Minhao Wu, Lin Wang, Jianye Zang, and Qing Lin*, titled "A Biosynthetic Route to Photoclick Chemistry on Proteins" J. Am. Chem. Soc.,2010,132, 14812–14818.

   14.以合作作者发表的研究论文: Wenjiao Song, Yizhong Wang, Zhipeng Yu, Claudia I. Rivera Vera, Jun Qu, and Qing Lin*, titled "A Metabolic Alkene Reporter for Spatiotemporally Controlled Imaging of Newly Synthesized Proteins in Mammalian Cells" ACS Chem. Biol.,2010,5, 875–885 (Cover Article). 

   15.以合作作者发表的研究论文: Wenjiao Song, Zhipeng Yu, Michael M. Madden and Qing Lin*, titled "A bioorthogonal chemistry strategy for probing protein lipidation in live cells" Mol. BioSyst.,2010,6,1576-1578 .

   16.以第一作者发表的研究论文: Zhipeng Yu, Xiaohua Liu, Lin Zhou, Lili Lin, Xiaoming Feng*, titled "Bifunctional Guanidine via an Amino Amide Skeleton for Asymmetric Michael Reactions of β-Ketoesters with Nitroolefins: A Concise Synthesis of Bicyclic β-Amino Acids" Angew. Chem. Int. Ed. 2009,48, 5195-5198. 

   17.以合作作者发表的研究论文:Shao-Liang Zheng, Yizhong Wang, Zhipeng Yu, Qing Lin*, and Philip Coppens*, titled "Direct Observation of a Photoinduced Nonstabilized Nitrile Imine Structure in the Solid State" J. Am. Chem. Soc. 2009,131, 18036-18037.

   18.以第一作者发表的研究论文: Zhipeng Yu, Xiaohua Liu, Zhenhua Dong, Mingsheng Xie, and Xiaoming Feng*, titled "An N,N’-Dioxide/In(OTf)₃ Catalyst for the Asymmetric Hetero-Diels-Alder Reaction Between Danishefsky’s Dienes and Aldehydes: Application in the Total Synthesis of Triketide". Angew. Chem. Int. Ed. 2008,47, 1308-1311. 

   19.以合作作者发表的研究论文:Bo Gao, Zhipeng Yu, Zhengyan Fu and Xiaoming Feng*, titled "A Convenient and Versatile Approach to 2,3-dihydro-4H-pyran-4-ones via Tandem Aldol Reaction-conjugate Addition", Tetrahedron Letters. 2006,47, 1537-1539.

   20.以合作作者发表的研究论文:Bo Gao, Zhengyan Fu, Zhipeng Yu, Lan Yu, Yaozong Huang and Xiaoming Feng*, titled "Highly enantioselective hetero-Diels–Alder reaction between trans-1-methoxy-2-methyl-3-trimethyl-siloxybuta-1,3-diene and aldehydes catalyzed by (R)- BINOL-Ti(IV) complex", Tetrahedron. 2005,61, 5822-5830.

   21.以合作作者发表的研究论文:Ke Cheng, Baiqing Zeng, Zhipeng Yu, Bo Gao, Xiaoming Feng*, titled "A Mild and Efficient Synthesis of 2,5-disubstituted 2,3-Dihydro-4-pyridones Catalyzed by Yb(OTf)₃",Synlett.2005,1018-1020. 

   22.以合作作者发表的研究论文:Zhengyan Fu, Bo Gao, Zhipeng Yu, Lan Yu, Yaozhong Huang, Xiaoming Feng,* Guolin Zhang,* titled "An Efficient and Enantioselective Approach to 2,5-Disubstituted Dihyropyrones", Synlett.2004, 1772-1775.