代表性成果 (获奖成果、专著、论文、专利) |
(1) Hou, J.-T., Yu, K.-K., Sunwoo, K., Kim, W. Y., Koo, S., Wang, J., Ren, W. X., Wang, S.*, Yu, X.-Q.*, Kim, J. S.*, Fluorescent Imaging of Reactive Oxygen and Nitrogen Species Associated with Pathophysiological Processes, Chem,2020, 6, 832–866. (2) Shi, L., Liu, Y.-H., Li, K.*, Sharma, A., Yu, K.-K., Ji, M. S., Li, L.-L., Zhou, Q., Zhang, H., Kim, J. S.*, Yu, X.-Q.*, An AIE-Based Probe for Rapid and Ultrasensitive Imaging of Plasma Membranes in Biosystems, Angew. Chem. Int. Ed.,2020, DOI: 10.1002/anie.201909498. (3) Yu, K.-K., Li, K., Lu, C.-Y., Xie, Y.-M., Liu, Y.-H., Zhou, Q., Bao, J.-K.*, Yu, X.-Q.*, Multifunctional gold nanoparticles as smart nanovehicles with enhanced tumour-targeting abilities for intracellular pH mapping and in vivo MR/fluorescence imaging, Nanoscale,2020,12, 2002–2010. (4) Shi, L., Li, K.*, Liu, Y.-H., Liu, X., Zhou, Q., Xu, Q., Chen, S.-Y., Yu, X.-Q.*, Bio-inspired assembly in a phospholipid bilayer: effective regulation of electrostatic and hydrophobic interactions for plasma membrane specific probes, Chem. Commun., 2020,56, 3661—3664. (5) Wang, N., Yu, K.-K., Shan, Y.-M., Li, K.*, Tian, J., Yu, X.-Q.*, Wei, X.*, HClO/ClO−‑Indicative Interpenetrating Polymer Network Hydrogels as Intelligent Bioactive Materials for Wound Healing, ACS Appl. Bio Mater., 2020,3, 37−44. (6) He, X., Luo, Q., Zhang, J.*, Chen, P., Wang, H.-J., Luo, K., Yu, X.-Q.*, Gadolinium-doped carbon dots as nano-theranostic agents for MR/FL diagnosis and gene delivery, Nanoscale,2019,11, 12973–12982. (7) Zhou, Q., Li, K.*, Li, L.-L., Yu, K.-K., Zhang, H., Shi, L., Chen, H., Yu, X.-Q.*, Combining Wittig Olefination with Photoassisted Domino Reaction To Distinguish 5‑Formylcytosine from 5-Formyluracil,Anal. Chem.,2019,91, 9366−9370. (8) Li, J., Hu, Z.-E, Yang, X.-L., Wu, W.-X., Xing, X., Gu, B., Liu, Y.-H., Wang, N.*, Yu, X.-Q.*, GSH/pH dual-responsive biodegradable camptothecin polymeric prodrugs combined with doxorubicin for synergistic anticancer efficiency, Biomater. Sci.,2019,7, 3277–3286. (9) Liu, B.-Y., Yang, X.-L., Xing, X., Li, J., Liu, Y.-H., Wang, N.*, Yu, X.-Q.*, Trackable Water-Soluble Prodrug Micelles Capable of Rapid Mitochondrial-Targeting and Alkaline pH-Responsive Drug Release for Highly Improved Anticancer Efficacy, ACS Macro Lett.,2019,8, 719−723. (10) Li, K., Li, L.-L., Zhou, Q., Yu, K.-K., Kim, J. S.*, Yu, X.-Q.*, Reaction-based fluorescent probes for SO 2 derivatives and their biological applications, Coord. Chem. Rev.,2019,388, 310-333. (11) Feng, M.-L., Li, S.-Q., He, H.-Z., Xi, L.-Y., Chen, S.-Y.*, Yu, X.-Q.*, Electrochemically initiated intermolecular C–N formation/cyclization of ketones with 2-aminopyridines: an efficient method for the synthesis of imidazo[1,2-a]pyridines, Green Chem.,2019,21, 1619-1624. (12) Li, L.-L., Xu, H.-R., Li, K.*, Yang, Q., Pan, S.-L., Yu, X.-Q.*, Mitochondrial G-quadruplex targeting probe with near-infrared fluorescence emission, Sensors Actuators: B. Chem.,2019,286, 575-582. (13) Yu, Q.-Y., Guo, Y., Zhang, J.*, Huang, Z., Yu, X.-Q.*, Zn( II ) coordination to cyclen-based polycations for enhanced gene delivery, J. Mater. Chem. B, 2019,7, 451-459. (14) He, X., Chen, P., Zhang, J.*, Luo, T.-Y., Wang, H.-J., Liu, Y.-H., Yu, X.-Q.*, Cationic polymer-derived carbon dots for enhanced gene delivery and cell imaging, Biomater. Sci.,2019,7, 1940-1948. (15) Shi, L., Li, K.*, Li, L.-L., Chen, S.-Y., Li, M.-Y., Zhou, Q., Wang, N., Yu, X.-Q.*, Novel easily available purine-based AIEgens with colour tunability and applications in lipid droplet imaging, Chem. Sci.,2018, 9, 8969–8974. (16) Li, L.-L., Li, K.*, Li, M.-Y., Shi, L., Liu, Y.-H., Zhang, H., Pan, S.-L., Wang, N., Zhou, Q., Yu, X.-Q.*, BODIPY-Based Two-Photon Fluorescent Probe for Real-Time Monitoring of Lysosomal Viscosity with Fluorescence Lifetime Imaging Microscopy, Anal. Chem.,2018,90, 5873-5878. (17) Zhang, Y.-M., Huang, Z., Wu, X.-R., Zhang, J.*, Liu, Y.-H., Yu, X.-Q.*, Small Combinatorial Library of Lipidoids as Nanovectors for Gene Delivery, ACS Appl. Nano Mater.,2018,1, 3925-3934. (18) Zhou, Q., Li, K.*, Liu, Y.-H., Li, L.-L., Yu, K.-K., Zhang, H., Yu, X.-Q.*, Fluorescent Wittig reagent as a novel ratiometric probe for the quantification of 5-formyluracil and its application in cell imaging, Chem. Commun.,2018,54, 13722-13725. (19) Pan, S.-L., Li, K.*, Li, L.-L., Li, M.-Y., Shi, L., Liu, Y.-H., Yu, X.-Q.*, A reaction-based ratiometric fluorescent sensor for the detection of Hg( II ) ions in both cells and bacteria, Chem. Commun.,2018,54, 4955-4958. (20) Li, J., Yang, X.-L., Liu, Y.-H., Wu, W.-X., Liu, B.-Y., Wang, N.*, Yu, X.-Q.*, Chemoenzymatic synthesis of dual-responsive graft copolymers for drug delivery: long-term stability, high loading and cell selectivity, J. Mater. Chem. B,2018,6, 6993-7003. (21) Wu, M.-Y.*, Wang, Y., Liu, Y.-H., Yu, X.-Q.*, Dual-site lysosome-targeted fluorescent probe for separate detection of endogenous biothiols and SO2 in living cells, J. Mater. Chem. B,2018,6, 4232-4238. (22) Wang, B., Zhang, J.*, Liu, Y.-H., Zhang, W., Xiao, Y.-P., Zhao, R.-M., Yu, X.-Q.*, A reduction-responsive liposomal nanocarrier with self-reporting ability for efficient gene delivery, J. Mater. Chem. B,2018,6, 2860-2868. (23) Shi, L., Li, K.*, Cui, P.-C., Li, L.-L., Pan, S.-L., Li, M.-Y., Yu, X.-Q.*, BINOL derivatives with aggression-induced emission, J. Mater. Chem. B, 2018,6, 4413-4416. (24) Hou, J.-T., Ren, W. X., Li, K., Seo, J., Sharma, A., Yu, X.-Q.*, Kim, J. S.*, Fluorescent bioimaging of pH: from design to applications, Chem. Soc. Rev.,2017,46, 2076-2090. (25) Wang, S., Chen, S.-Y.*, Yu, X.-Q.*, C–H functionalization by high-valent Cp*Co(III) catalysis, Chem. Commun.,2017,53, 3165-3180. (26) Xiao, Y.-P., Zhang, J.,* Liu, Y.-H., Huang, Z., Wang, B., Zhang, Y.-M., Yu, X.-Q.*, Cross-linked polymers with fluorinated bridges for efficient gene delivery, J. Mater. Chem. B,2017,5, 8542-8553. (27) Zhang, W., Wang, N.,* Liu, Y.-H., Jiao, S.-Y., Zhang, W.-W., Pu, X.-M., Yu, X.-Q.*, 1,4-Dihydropyridines: discovery of minimal AIEEgens and their mitochondrial imaging applications, J. Mater. Chem. B,2017,5, 464-469. (28) Wang, H.-J., He, X., Luo, T.-Y., Zhang, J.,* Liu, Y.-H., Yu, X.-Q.*, Amphiphilic carbon dots as versatile vectors for nucleic acid and drug delivery, Nanoscale,2017,9, 5935-5947. (29) Hu, L., Yu, S.,* Wang, Y., Yu, X.*, Pu, L.*, Enhanced Fluorescence of 3,3′-Diformyl BINOL by Functional Secondary Amines, Org. Lett.,2017,19, 3779-3782. (30) Luan, C.-R., Liu, Y.-H., Zhang, J.*, Yu, Q.-Y., Huang, Z., Wang, B., Yu, X.-Q.*, Low Molecular Weight Oligomers with Aromatic Backbone as Efficient Nonviral Gene Vectors, ACS Appl. Mater. Interfaces,2016,8, 10743−10751. (31) Yu, K.-K., Li, K.*, Qin, H.-H., Zhou, Q., Qian, C.-H., Liu, Y.-H., Yu, X.-Q.*, Construction of pH-Sensitive “Submarine” Based on Gold Nanoparticles with Double Insurance for Intracellular pH Mapping, Quantifying of Whole Cells and in Vivo Applications, ACS Appl. Mater. Interfaces,2016,8, 22839−22848. (32) Yang, J., Li, K.*, Hou, J.-T., Li, L.-L., Lu, C.-Y., Xie, Y.-M., Wang, X., Yu, X.-Q.*, Novel Tumor-Specific and Mitochondria-Targeted near-Infrared-Emission Fluorescent Probe for SO2 Derivatives in Living Cells, ACS Sens.,2016,1, 166−172. (33) Liu, Y., Li, K.*, Xie, K.-X., Li, L.-L., Yu, K.-K., Wang, X., Yu, X.-Q.*, A water-soluble and fast-response mitochondriatargeted fluorescent probe for colorimetric and ratiometric sensing of endogenously generated SO2 derivatives in living cells, Chem. Commun.,2016,52, 3430—3433. (34) Wang, S., Hou, J.-T., Feng, M.-L., Zhang, X.-Z., Chen, S.-Y.*, Yu, X.-Q.*, Cobalt(III)-catalyzed alkenylation of arenes and 6-arylpurines with terminal alkynes: efficient access to functional dyes, Chem. Commun.,2016,52, 2709—2712. (35) Huang, Z., Zhang, Y.-M., Cheng, Q., Zhang, J.*, Liu, Y.-H., Wang, B., Yu, X,-Q,*, Structure–activity relationship studies of symmetrical cationic bolasomes as non-viral gene vectors, J. Mater. Chem. B,2016,4, 5575—5584. (36) Zhang, R.-Y., Xi, L.-Y., Shi, L., Zhang, X.-Z., Chen, S.-Y.*, Yu, X.-Q.*, Metal-Free Oxidative Radical Alkynylation/Ring Expansion Rearrangement of Alkenyl Cyclobutanols with Ethynylbenziodoxolones, Org. Lett.,2016,18, 4024−4027. (37). Wen, K., Yu, S.*, Huang, Z., Chen, L., Xiao, M., Yu, X.-Q.*, Pu, L.*, Rational Design of a Fluorescent Sensor to Simultaneously Determine Both the Enantiomeric Composition and the Concentration of Chiral Functional Amines, J. Am. Chem. Soc.,2015,137, 4517−4524. (38). Wu, M.-Y., Li, K.*, Liu, Y.-H., Yu, K.-K., Xie, Y.-M., Zhou, X.-D.*, Yu, X.-Q.*, Mitochondria-targeted ratiometric fluorescent probe for real time monitoring of pH in living cells, Biomaterials,2015,53, 669-678. (39). Hou, J.-T., Li, K.*, Yang, J., Yu, K.-K., Liao, Y.-X., Ran, Y.-Z., Liu, Y.-H., Zhou, X.-D.*, Yu, X.-Q.*, A ratiometric fluorescent probe for in situ quantification of basal mitochondrial hypochlorite in cancer cells, Chem. Commun.,2015, 51, 6781-6784. (40). Chen, S.-Y., Liu, W., Wu, X., Ying, J., Yu, X.*, Pu, L.*, A Lewis acid activated reaction of Zn with EtI to promote highly enantioselective alkyne additions to aldehydes, Chem. Commun.,2015,51, 358-361. (41). Liu, Y., Li, K.*, Wu, M.-Y., Liu, Y.-H., Xie, Y.-M.*, Yu, X.-Q.*, A mitochondria-targeted colorimetric and ratiometric fluorescent probe for biological SO2 derivatives in living cells, Chem. Commun.,2015, 51, 10236-10239. (42). Guo, Q., Liu, Y.-H., Xun, M.-M., Zhang, J.*, Huang, Z., Zhou, X.-D.*, Yu, X.-Q.*, Diol glycidyl ether-bridged low molecular weight PEI as potential gene delivery vehicles, J. Mater. Chem. B,2015,3, 2660-2670. (43). Wang, M.-Q., Zhang, H., Zhang, W., Zhao, Y., Yasmeen, A., Zhou, L., Yu, X.-Q.*, Tang, Z.*, In vitro selection of DNA-cleaving deoxyribozyme with site-specific thymidine excision activity, Nucleic Acids Research,2014,42,9262-9269. (44). Huang, Z., Yu, S., Wen, K., Yu, X.-Q.*, Pu, L.*, Zn(II) promoted dramatic enhancement in the enantioselective fluorescent recognition of functional chiral amines by a chiral aldehyde, Chem. Sci.,2014,5, 3457-3462. (45). Yi, W.-J.,Yu, X.-C.,Wang, B.,Zhang, J.*,Yu, Q.-Y., Zhou, X.-D.*, Yu, X.-Q.*,TACN-based oligomers with aromatic backbones for efficient nucleic acid delivery, Chem. Commun., 2014,50, 6454-6457. (46). Wang, S., Guo, R., Wang, G., Chen, S.-Y.*, Yu, X.-Q.*, Copper-catalyzed phosphorylation of sp2 C–H bonds, Chem. Commun.,2014,50, 12718-12721. (47). Hou, J.-T.,Wu, M.-Y.,Li, K.*,Yang, J.,Yu, K.-K.,Xie, Y.-M.*,Yu, X.-Q.*,Mitochondria-targeted colorimetric andfluorescent probes for hypochlorite and theirapplications for in vivo imaging, Chem. Commun.,2014,50, 8640-8643. (48). Hou, J.-T.,Yang, J.,Li, K.*,Liao, Y.-X.,Yu, K.-K.,Xie, Y.-M., Yu, X.-Q.*,A highly selective water-soluble optical probe for endogenous peroxynitrite, Chem. Commun.,2014,50, 9947-9950. (49). Xi, L.-Y., Zhang, R.-Y., Liang, S., Chen, S.-Y.*, Yu, X.-Q.*, Copper-Catalyzed Aerobic Synthesis of 2‑Arylpyridines from Acetophenones and 1,3-Diaminopropane, Org. Lett.,2014,16, 5269−5271. (50). Zhang, Q.-F.,Yu, Q.-Y.,Geng, Y.,Zhang, J.*,Wu, W.-X.,Wang, G., Gu, Z.*,Yu, X.-Q.*, Ring-Opening Polymerization for Hyperbranched Polycationic Gene Delivery Vectors with Excellent Serum Tolerance, ACS Appl. Mater. Interfaces,2014,6, 15733−15742. (51).Wang, H.-J., Liu, Y.-H., Zhang, J.*, Zhang, Y., Xia, Y., Yu, X.-Q.*, Cyclen-based cationic lipids with double hydrophobic tails for efficient gene delivery, Biomater. Sci.,2014,2, 1460-1470. (52).Yi, W.-J., Zhang, Q.-F., Zhang, J.*, Liu, Q., Ren, L., Chen, Q.-M., Guo, L., Yu, X.-Q.*, Cyclen-based lipidic oligomers as potential gene delivery vehicles, Acta Biomaterialia,2014,10, 1412-1422. (53).Wu, M.-Y., Li, K.*, Li, C.-Y., Hou, J.-T., Yu, X.-Q.*, A water-soluble near-infrared probe for colorimetric and ratiometric sensing of SO2 derivatives in living cells, Chem. Commun., 2014,50, 183-185. (54).Zhang, Q.-F., Yi, W.-J., Wang, B., Zhang, J.*, Ren, L.-F., Chen, Q.-M., Guo, L.-D.*, Yu, X.-Q.*, Linear polycations by ring-opening polymerization as non-viral gene delivery vectors, Biomaterials,2013,34, 5391-5401. (55).Chen, W., Tay, J.-H. Ying, J., Sabat, M., Yu, X.-Q.*, Pu, L.*,A quick access to the spirotricyclic core analogue of mangicol A by a Rh( I )-catalyzed tandem Pauson–Khand/[4+2] cycloaddition, Chem. Commun.,2013, 49, 170-172. (56). Du, J., Huang, Z., Yu, X.-Q.*, Pu, L.*, Highly selective fluorescent recognition of histidine by a crown ether–terpyridine–Zn(II) sensor, Chem. Commun., 2013,49, 5399--5401. (57). Wang, J., Wang, S., Wang, G., Zhang, J.*, Yu, X.-Q.*, Iron-mediated direct arylation with arylboronic acids through an aryl radical transfer pathway, Chem. Commun.,2012, 48, 11769–11771. (58). Huang, Z., Du, J., Zhang, J., Yu, X.-Q.*, Pu, L.*, A simple and efficient fluorescent sensor for histidine, Chem. Commun.,2012,48, 3412-3414. (59). Wang, J., Hou, J.-T., Wen, J., Zhang, J.*, Yu, X.-Q.*, Iron-catalyzed direct amination of azoles using formamides or amines as nitrogen sources in air, Chem. Commun.,2011, 47, 3652-3654. (60).Wang,M.-Q., Liu,J.-L., Wang,J.-Y., Zhang,D.-W., Zhang,J., Streckenbach,F., Tang,Z.*, Lin,H.-H.*, Liu,Y., Zhao,Y.-F.,Yu,X.-Q.*,Site-selective DNA Hydrolysis Induced by a Metal-free Peptide Nucleic Acid-Cyclen Conjugate,Chem. Commun., 2011,47, 11059-11061. (61). Feng, X.-W., Wang, J., Zhang, J., Yang, J., Wang, N., Yu, X.-Q.*, Copper-Catalyzed Nitrogen Loss of Sulfonylhydrazones: A Reductive Strategy for the Synthesis of Sulfones from Carbonyl Compounds, Org. Lett.,2010,12, 4408-4411. (62).Chen, X., Huang, Z., Chen, S.-Y., Li, K., Yu, X.-Q.*, Pu, L.*, Enantioselective Gel Collapsing: A New Means of Visual Chiral Sensing, J. Am. Chem. Soc., 2010,132, 7297–7299. (63). Wen, J., Qin, S., Ma, L.-F., Dong, L., Zhang, J., Liu, S.-S., Duan, Y.-S., Chen, S.-Y., Hu, C.-W.*, Yu, X.-Q.*, Iron-Mediated Direct Suzuki-Miyaura Reaction: A New Method for the ortho-Arylation of Pyrrole and Pyridine, Org. Lett.,2010,12, 2694-2697. (64). Zhang, J., Meng, X.-G., Zeng, X.-C., Yu, X.-Q.*, Metallomicellar supramolecular systems and their applications in catalytic reactions, Coord. Chem. Rev.,2009,253, 2166–2177. (65). Lu, Q.-S., Dong, L., Zhang, J., Li, J., Jiang, L., Huang, Y., Qin, S., Hu, C.-W., Yu, X.-Q.*, Imidazolium-Functionalized BINOL as a Multifunctional Receptor for Chromogenic and Chiral Anion Recognition, Org. Lett.,2009, 11, 669-672. (66). Li, K., He, T., Li, C., Feng, X.-W., Wang, N., Yu, X.-Q.*, Lipase-catalysed direct Mannich reaction in water: utilization of biocatalytic promiscuity to C-C bond formation in a “one-pot” synthesis, Green Chem.,2009,11, 777-779. (67). Feng, X.-W., Li, C., Wang, N., Li, K., Zhang, W.-W., Wang, Z., Yu, X.-Q.*, Lipase-catalysed decarboxylative aldol reaction and decarboxylative Knoevenagel reaction, Green Chem.,2009, 11, 1933-1936. (68).Wen, J., Zhang, J., Chen, S.-Y., Li, J., Yu, X.-Q.*, Iron-Mediated Direct Arylation of Unactivated Arenes, Angew. Chem. Int. Ed.,2008,47, 8897-8900. (69). Li, C., Feng, X.-W., Wang, N., Zhou, Y.-J., Yu, X.-Q.*, Biocatalytic promiscuity: the first lipase-catalysed asymmetric aldol reaction, Green Chem., 2008, 10, 616-618. (70). Yang, X.-B., Feng, J., Zhang, J., Wang, N., Wang, L., Liu, J.-L., Yu, X.-Q*, Highly Enantioselective Hetero-Diels-Alder Reaction of trans-1-Methoxy-2-methyl-3-trimethylsiloxybuta-1,3-diene with Aromatic and Aliphatic Aldehydes Catalyzed by 3-Substituted BINOL-Titanium Complex, Org. Lett.,2008,10, 1299-1302. (71). He, L., Yu, J., Zhang, J., Yu, X.-Q.*, -Amidation of cyclic ethers catalyzed by simple copper salts and a mild and efficient preparation method for ,-aminoalcohols, Org. Lett., 2007,9, 2277-2280. (72). Gao, G., Wang, Q., Yu, X.-Q.*, Xie, R.-G., Pu, L., Highly Enantioselective Synthesis of -Hydroxy--acetylenic Esters by Asymmetric AlkyneAddition to Aldehydes, Angew. Chem. Int. Ed.2006,45, 122-125. (73). Lan, J.-B.; Chen, L.; Yu, X.-Q. *; You, J.-S.; Xie, R.-G., A simple copper salt catalysed the coupling of imidazole with arylboronic acids in protic solvent, Chem. Commun.,2004, 188-189. (74). Liang, J.-L.; Yu, X.-Q.; Che, C.-M., Amidation of silyl enol ethers and cholesteryl acetates with chiral ruthenium(II) Schiff base catalysts: catalytic and enantioselective studies, Chem. Commun.,2002, 124~125. (75). You, J.-S.; Yu, X.-Q.; Zhang, G.-L.; Xiang, Q.-X.; Lan, J.-B.; Xie, R.-G., Novel chiral imidazole cyclophane receptors: Synthesis and enantioselective recoginition for amino acid derivatives, Chem. Commun.,2001, 1816~1817. (76).Yu,X.-Q.; Huang, J.-S.; Yu, W.-Y.; Che, C.-M., Polymer-supported ruthenium porphyrins: Versatile and robust epoxidation catalysts with unusual selectivity, J. Am. Chem. Soc.,2000,122, 5337~5342. (77).Yu, X.-Q.; Huang, J.-S.; Zhou, X.-G.; Che, C.-M., Amidation of saturated C-H bonds catalyzed by electron-deficient ruthenium and manganese porphyrins. A highly catalytic nitrogen atom transfer process, Org. Lett.,2000, 2, 2233~2236. |
